Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus
Joint Authors
Chen, Feng
Ai, Tingting
Zhou, Shaonan
Zhang, Jieni
Zheng, Hui
Zhou, Yanheng
Hu, Wei
Liu, Xiaofei
Li, Li
Lin, Jiuxiang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gestational diabetes mellitus (GDM) is a frequent medical condition during pregnancy.
Early diagnosis and treatment of GDM are crucial for both the mother and the baby.
In the present study, we aimed to identify specific biomarkers to assist in the early detection of GDM and give some clues to the possible causes of GDM by comparing serum peptide profile differences between GDM patients and healthy controls.
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used in combination with weak cation exchange magnetic bead (WCX-MB).
Levels of four peptides (4418.9, 2219.7, 2211.5, and 1533.4 Da) were significantly different.
Interestingly, three of them (4418.9, 2211.5, and 1533.4 Da) were identified when GDM patients with two degrees of glucose intolerance were compared.
Additionally, peptides 2211.5 and 1533.4 Da showed a decreasing trend as glucose intolerance increased, while peptide 4418.9 Da exhibited the reverse tendency.
In conclusion, our study provides novel insights into the altered serum peptide profile of GDM patients.
The specific candidate biomarkers may contribute to the development of GDM.
American Psychological Association (APA)
Ai, Tingting& Chen, Feng& Zhou, Shaonan& Zhang, Jieni& Zheng, Hui& Zhou, Yanheng…[et al.]. 2015. Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056018
Modern Language Association (MLA)
Ai, Tingting…[et al.]. Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056018
American Medical Association (AMA)
Ai, Tingting& Chen, Feng& Zhou, Shaonan& Zhang, Jieni& Zheng, Hui& Zhou, Yanheng…[et al.]. Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056018