Prognostic Significance of the Tumor-Stroma Ratio in Epithelial Ovarian Cancer
Joint Authors
Chen, Ying
Zhang, Lei
Liu, Wenxin
Liu, Xiangyu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tumor-stroma ratio (TSR) has recently been identified as a promising prognostic parameter for several solid tumors.
This study aimed to evaluate the prognostic role of TSR in epithelial ovarian cancer (EOC) and 838 EOC patients were enrolled in this study.
TSR was estimated on hematoxylin-and-eosin-stained tissue sections from the most invasive part of the primary tumor.
Patients were classified as stroma-rich or stroma-poor according to the proportion of stroma ≥50% or <50%.
Chi-square test analysis revealed that TSR were significantly associated with FIGO stage, LN status, and recurrence or not (all of them P<0.001).
The higher stroma-rich proportions were found in EOC patients with advanced stage (36.13% versus 19.75%), LN metastasis (51.93% versus 27.25%), and recurrence (34.27% versus 6.82%).
Stroma-rich EOC patients had obvious shorter median time of progression-free survival (29 versus 39 months) and overall survival (50 versus 58 months), respectively.
TSR was an independent prognostic factor for the evaluation of PFS in EOC.
Stroma-rich tumors had worse prognosis and higher risk of relapse compared with those in stroma-poor tumors in EOC patients.
Considered easy to determine for routine pathological examination, TSR may serve as a new prognostic histological parameter in EOC.
American Psychological Association (APA)
Chen, Ying& Zhang, Lei& Liu, Wenxin& Liu, Xiangyu. 2015. Prognostic Significance of the Tumor-Stroma Ratio in Epithelial Ovarian Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056028
Modern Language Association (MLA)
Chen, Ying…[et al.]. Prognostic Significance of the Tumor-Stroma Ratio in Epithelial Ovarian Cancer. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056028
American Medical Association (AMA)
Chen, Ying& Zhang, Lei& Liu, Wenxin& Liu, Xiangyu. Prognostic Significance of the Tumor-Stroma Ratio in Epithelial Ovarian Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056028