Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children
Joint Authors
Petrone, Linda
Cannas, Angela
Aloi, Francesco
Nsubuga, Martin
Sserumkuma, Joseph
Nazziwa, Ritah Angella
Jugheli, Levan
Lukindo, Tedson
Reither, Klaus
Girardi, Enrico
Goletti, Delia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objectives.
Interferon-γ inducible protein 10 (IP-10), either in blood or in urine, has been proposed as a tuberculosis (TB) biomarker for adults.
This study aims to evaluate the potential of IP-10 diagnostics in children from Uganda, a high TB-endemic country.
Methods.
IP-10 was measured in the blood and urine concomitantly taken from children who were prospectively enrolled with suspected active TB, with or without HIV infection.
Clinical/microbiological parameters and commercially available TB-immune assays (tuberculin skin test (TST) and QuantiFERON TB-Gold In-Tube (QFT-IT)) were concomitantly evaluated.
Results.
One hundred twenty-eight children were prospectively enrolled.
The analysis was performed on 111 children: 80 (72%) of them were HIV-uninfected and 31 (27.9%) were HIV-infected.
Thirty-three healthy adult donors (HAD) were included as controls.
The data showed that IP-10 is detectable in the urine and blood of children with active TB, independent of HIV status and age.
However, although IP-10 levels were higher in active TB children compared to HAD, the accuracy of identifying “active TB” was low and similar to the TST and QFT-IT.
Conclusion.
IP-10 levels are higher in children with respiratory illness compared to controls, independent of “TB status” suggesting that the evaluation of this parameter can be used as an inflammatory marker more than a TB test.
American Psychological Association (APA)
Petrone, Linda& Cannas, Angela& Aloi, Francesco& Nsubuga, Martin& Sserumkuma, Joseph& Nazziwa, Ritah Angella…[et al.]. 2015. Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056029
Modern Language Association (MLA)
Petrone, Linda…[et al.]. Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056029
American Medical Association (AMA)
Petrone, Linda& Cannas, Angela& Aloi, Francesco& Nsubuga, Martin& Sserumkuma, Joseph& Nazziwa, Ritah Angella…[et al.]. Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056029