Expression Pattern of Transcription Factors and Intracellular Cytokines Reveals That Clinically Cured Tuberculosis Is Accompanied by an Increase in Mycobacterium-Specific Th1, Th2, and Th17 Cells
Joint Authors
Castellano, Lúcio Roberto
Vinícius da Silva, Marcos
Massaro Junior, Vladimir J.
Silva, Djalma A. A.
Alexandre, Patricia B. D.
Rodrigues, Denise Bertulucci Rocha
Rodrigues, Virmondes
Machado, Juliana Reis
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Tuberculosis (TB) remains a major global health problem and is the second biggest cause of death by infectious disease worldwide.
Here, we investigate in vitro the Th1, Th2, Th17, and Treg cytokines and transcriptional factors produced after Mycobacterium-specific antigen stimulation in patients with active pulmonary tuberculosis, clinically cured pulmonary tuberculosis, and healthy donors with a positive tuberculin skin test (TST+).
Together, our data indicate that clinical cure after treatment increases the percentages of Mycobacterium-specific Th1, Th2, and Th17 cells compared with those found in active-TB and TST+ healthy donors.
These results show that the host-parasite equilibrium in latent TB breaks in favor of the microorganism and that the subsequent clinical recovery posttreatment does not return the percentage levels of such cells to those observed in latent tuberculosis.
Additionally, our results indicate that rather than showing an increase in the percentage of Mycobacterium-specific Tregs, active-TB patients display lower Th1 : Treg and Th17 : Treg ratios.
These data, together with lower Th1 : Th2 and Th17 : Th2 ratios, may indicate a mechanism by which the breakdown of the host-parasite equilibrium leads to active-TB and changes in the repertoire of Mycobacterium-specific Th cells that are associated with clinical cure after treatment of pulmonary tuberculosis.
American Psychological Association (APA)
Vinícius da Silva, Marcos& Massaro Junior, Vladimir J.& Machado, Juliana Reis& Silva, Djalma A. A.& Castellano, Lúcio Roberto& Alexandre, Patricia B. D.…[et al.]. 2015. Expression Pattern of Transcription Factors and Intracellular Cytokines Reveals That Clinically Cured Tuberculosis Is Accompanied by an Increase in Mycobacterium-Specific Th1, Th2, and Th17 Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056035
Modern Language Association (MLA)
Vinícius da Silva, Marcos…[et al.]. Expression Pattern of Transcription Factors and Intracellular Cytokines Reveals That Clinically Cured Tuberculosis Is Accompanied by an Increase in Mycobacterium-Specific Th1, Th2, and Th17 Cells. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1056035
American Medical Association (AMA)
Vinícius da Silva, Marcos& Massaro Junior, Vladimir J.& Machado, Juliana Reis& Silva, Djalma A. A.& Castellano, Lúcio Roberto& Alexandre, Patricia B. D.…[et al.]. Expression Pattern of Transcription Factors and Intracellular Cytokines Reveals That Clinically Cured Tuberculosis Is Accompanied by an Increase in Mycobacterium-Specific Th1, Th2, and Th17 Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056035