Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study
Joint Authors
Park, Seok-Won
Park, Jong-Seok
Lim, Youn-Mook
Kim, Bo Hae
Kim, Hee-Bok
Park, EunJi
Choi, Se In
Kwon, Tack-Kyun
Kwon, Seong Keun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study explored a novel strategy to restore the vocal gap by using cross-linked β-glucan hydrogel by γ-irradiation.
An aqueous solution of 5 wt% β-glucan was prepared and cross-linked using 60Co γ irradiation.
Ten nude mice were injected with 0.8 mL of irradiated β-glucan on the left back and the same volume of nonirradiated β-glucan on the right back for comparison.
The mice were sacrificed at 1 and 2 weeks after injection and histological evaluations were performed.
Irradiated β-glucan demonstrated a significantly larger volume than nonirradiated β-glucan in the back of nude mice with less inflammatory reaction.
After unilateral recurrent laryngeal nerve section in New Zealand White rabbits, irradiated and nonirradiated β-glucan were injected into paralyzed vocal folds.
Irradiated β-glucan remained at the paralyzed vocal fold without definite inflammatory signs on endoscopy.
High-speed recordings of vocal fold vibration showed decreased vocal gap in irradiated group compared to nonirradiated group.
Histologically, the laryngeal epithelium and lamina propria remained intact, without inflammatory cell infiltration.
Our newly developed injection material, irradiated β-glucan, showed excellent biocompatibility and remained longer than nonirradiated β-glucan in vivo, suggesting irradiated hydrogels as a new therapeutic approach that may be useful for the long-term treatment of vocal fold palsy.
American Psychological Association (APA)
Lim, Youn-Mook& Kim, Bo Hae& Kim, Hee-Bok& Park, EunJi& Park, Seok-Won& Park, Jong-Seok…[et al.]. 2015. Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056041
Modern Language Association (MLA)
Lim, Youn-Mook…[et al.]. Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056041
American Medical Association (AMA)
Lim, Youn-Mook& Kim, Bo Hae& Kim, Hee-Bok& Park, EunJi& Park, Seok-Won& Park, Jong-Seok…[et al.]. Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056041