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Attenuating Tumour Angiogenesis: A Preventive Role of Metformin against Breast Cancer
Joint Authors
Gao, Shan
Jiang, Jingcheng
Li, Pan
Song, Huijuan
Wang, Weiwei
Li, Chen
Kong, Deling
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Metformin is one of the most widely prescribed antidiabetics for type 2 diabetes.
A critical role of metformin against tumorigenesis has recently been implicated, although several studies also reported the lack of anticancer property of the antidiabetics.
Given the controversies regarding the potential role of metformin against tumour progression, the effect of metformin against breast, cervical, and ovarian tumour cell lines was examined followed by in vivo assessment of metformin on tumour growth using xenograft breast cancer models.
Significant inhibitory impact of metformin was observed in MCF-7, HeLa, and SKOV-3 cells, suggesting an antiproliferative property of metformin against breast, cervical, and ovarian tumour cells, respectively, with the breast tumour cells, MCF-7, being the most responsive.
In vivo assessment was subsequently carried out, where mice with breast tumours were treated with metformin (20 mg/kg body weight) or sterile PBS solution for 15 consecutive days.
No inhibition of breast tumour progression was detected.
However, tumour necrosis was significantly increased in the metformin-treated group, accompanied by decreased capillary formation within the tumours.
Thus, despite the lack of short-term benefit of metformin against tumour progression, a preventive role of metformin against breast cancer was implicated, which is at partially attributable to the attenuation of tumour angiogenesis.
American Psychological Association (APA)
Gao, Shan& Jiang, Jingcheng& Li, Pan& Song, Huijuan& Wang, Weiwei& Li, Chen…[et al.]. 2015. Attenuating Tumour Angiogenesis: A Preventive Role of Metformin against Breast Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056043
Modern Language Association (MLA)
Gao, Shan…[et al.]. Attenuating Tumour Angiogenesis: A Preventive Role of Metformin against Breast Cancer. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056043
American Medical Association (AMA)
Gao, Shan& Jiang, Jingcheng& Li, Pan& Song, Huijuan& Wang, Weiwei& Li, Chen…[et al.]. Attenuating Tumour Angiogenesis: A Preventive Role of Metformin against Breast Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056043