Study of Osteoarthritis Treatment with Anti-Inflammatory Drugs: Cyclooxygenase-2 Inhibitor and Steroids
Joint Authors
Cho, Hongsik
Walker, Andrew
Williams, Jeb
Hasty, Karen A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Patients with osteoarthritis (OA), a condition characterized by cartilage degradation, are often treated with steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2 (COX-2) selective NSAIDs.
Due to their inhibition of the inflammatory cascade, the drugs affect the balance of matrix metalloproteinases (MMPs) and inflammatory cytokines, resulting in preservation of extracellular matrix (ECM).
To compare the effects of these treatments on chondrocyte metabolism, TNF-α was incubated with cultured chondrocytes to mimic a proinflammatory environment with increasing production of MMP-1 and prostaglandin E2 (PGE2).
The chondrocytes were then treated with either a steroid (prednisone), a nonspecific COX inhibitor NSAID (piroxicam), or a COX-2 selective NSAID (celecoxib).
Both prednisone and celecoxib decreased MMP-1 and PGE-2 production while the nonspecific piroxicam decreased only the latter.
Both prednisone and celecoxib decreased gene expression of MMP-1 and increased expression of aggrecan.
Increased gene expression of type II collagen was also noted with celecoxib.
The nonspecific piroxicam did not show these effects.
The efficacy of celecoxib in vivo was investigated using a posttraumatic OA (PTOA) mouse model.
In vivo, celecoxib increases aggrecan synthesis and suppresses MMP-1.
In conclusion, this study demonstrates that celecoxib and steroids exert similar effects on MMP-1 and PGE2 production in vitro and that celecoxib may demonstrate beneficial effects on anabolic metabolism in vivo.
American Psychological Association (APA)
Cho, Hongsik& Walker, Andrew& Williams, Jeb& Hasty, Karen A.. 2015. Study of Osteoarthritis Treatment with Anti-Inflammatory Drugs: Cyclooxygenase-2 Inhibitor and Steroids. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056054
Modern Language Association (MLA)
Cho, Hongsik…[et al.]. Study of Osteoarthritis Treatment with Anti-Inflammatory Drugs: Cyclooxygenase-2 Inhibitor and Steroids. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056054
American Medical Association (AMA)
Cho, Hongsik& Walker, Andrew& Williams, Jeb& Hasty, Karen A.. Study of Osteoarthritis Treatment with Anti-Inflammatory Drugs: Cyclooxygenase-2 Inhibitor and Steroids. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056054