Recent Advances in Molecular Magnetic Resonance Imaging of Liver Fibrosis
Joint Authors
Sun, Jihong
Li, Zhiming
Yang, Xiaoming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Liver fibrosis is a life-threatening disease with high morbidity and mortality owing to its diverse causes.
Liver biopsy, as the current gold standard for diagnosing and staging liver fibrosis, has a number of limitations, including sample variability, relatively high cost, an invasive nature, and the potential of complications.
Most importantly, in clinical practice, patients often reject additional liver biopsies after initiating treatment despite their being necessary for long-term follow-up.
To resolve these problems, a number of different noninvasive imaging-based methods have been developed for accurate diagnosis of liver fibrosis.
However, these techniques only reflect morphological or perfusion-related alterations in the liver, and thus they are generally only useful for the diagnosis of late-stage liver fibrosis (liver cirrhosis), which is already characterized by “irreversible” anatomic and hemodynamic changes.
Thus, it is essential that new approaches are developed for accurately diagnosing early-stage liver fibrosis as at this stage the disease may be “reversed” by active treatment.
The development of molecular MR imaging technology has potential in this regard, as it facilitates noninvasive, target-specific imaging of liver fibrosis.
We provide an overview of recent advances in molecular MR imaging for the diagnosis and staging of liver fibrosis and we compare novel technologies with conventional MR imaging techniques.
American Psychological Association (APA)
Li, Zhiming& Sun, Jihong& Yang, Xiaoming. 2015. Recent Advances in Molecular Magnetic Resonance Imaging of Liver Fibrosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056055
Modern Language Association (MLA)
Li, Zhiming…[et al.]. Recent Advances in Molecular Magnetic Resonance Imaging of Liver Fibrosis. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056055
American Medical Association (AMA)
Li, Zhiming& Sun, Jihong& Yang, Xiaoming. Recent Advances in Molecular Magnetic Resonance Imaging of Liver Fibrosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056055