Treatment of Breakthrough and Refractory Chemotherapy-Induced Nausea and Vomiting
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Despite significant progress in the prevention of chemotherapy-induced nausea and vomiting (CINV) with the introduction of new antiemetic agents, 30–50% of patients receiving moderately or highly emetogenic chemotherapy (MEC or HEC) and guideline directed prophylactic antiemetics develop breakthrough CINV.
International guidelines recommend the treatment of breakthrough CINV with an agent from a drug class that was not used in the prophylactic antiemetic regimen and recommend using the breakthrough medication continuously rather than using it on an as needed basis.
There have been very few studies on the treatment of breakthrough CINV.
A recent double-blind, randomized, phase III study suggested that olanzapine may be an effective agent for the treatment of breakthrough CINV.
Refractory CINV occurs when patients develop CINV during subsequent cycles of chemotherapy when antiemetic prophylaxis has not been successful in controlling CINV in earlier cycles.
Patients who develop refractory CINV should be considered for a change in their prophylactic antiemetic regimen.
If significant anxiety exists, a benzodiazepine may be added to the prophylactic regimen.
If a refractory patient is receiving HEC, olanzapine may be added to the prophylactic regimen.
If the patient is receiving MEC, olanzapine or an NK-1 receptor antagonist may be added to the prophylactic regimen.
American Psychological Association (APA)
Navari, Rudolph M.. 2015. Treatment of Breakthrough and Refractory Chemotherapy-Induced Nausea and Vomiting. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056057
Modern Language Association (MLA)
Navari, Rudolph M.. Treatment of Breakthrough and Refractory Chemotherapy-Induced Nausea and Vomiting. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056057
American Medical Association (AMA)
Navari, Rudolph M.. Treatment of Breakthrough and Refractory Chemotherapy-Induced Nausea and Vomiting. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056057