Proteomic Analysis of Estrogen-Mediated Signal Transduction in Osteoclasts Formation
Joint Authors
Xiong, Qi
Tang, Peifu
Gao, Yanpan
Ge, Wei
Zhang, Lihai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Estrogen plays an important role in inhibiting osteoclast differentiation and protecting against bone loss from osteoporosis, especially in postmenopausal women.
However, the precise mechanisms underlying the effect of estrogen on osteoclasts are not well known.
In the present study, we performed proteomics analysis and bioinformatics analysis to comprehensively compare the differential expression of proteins in receptor activator of nuclear factor-κB ligand RANKL-induced osteoclasts in the presence and absence of estrogen.
We identified 6403 proteins, of which 124 were upregulated and 231 were downregulated by estrogen.
Bioinformatics analysis showed that estrogen treatment interfered with 77 intracellular pathways, including both confirmed canonical and unconfirmed pathways of osteoclast formation.
Our findings validate the inhibitory effect of estrogen on osteoclasts via the promotion of apoptosis and suppression of differentiation and polarization and suggest that estrogen might inhibit osteoclast formation via other pathways, which requires further investigation and verification.
American Psychological Association (APA)
Xiong, Qi& Tang, Peifu& Gao, Yanpan& Zhang, Lihai& Ge, Wei. 2015. Proteomic Analysis of Estrogen-Mediated Signal Transduction in Osteoclasts Formation. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056064
Modern Language Association (MLA)
Xiong, Qi…[et al.]. Proteomic Analysis of Estrogen-Mediated Signal Transduction in Osteoclasts Formation. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056064
American Medical Association (AMA)
Xiong, Qi& Tang, Peifu& Gao, Yanpan& Zhang, Lihai& Ge, Wei. Proteomic Analysis of Estrogen-Mediated Signal Transduction in Osteoclasts Formation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056064