Prevalence and Risk Factors of Prostate Cancer in Chinese Men with PSA 4–10 ngmL Who Underwent TRUS-Guided Prostate Biopsy: The Utilization of PAMD Score
Joint Authors
Zhou, Liqun
Ren, Da
Zhao, Chenglin
Wang, Rui
Wang, Huihui
Xi, Chenguang
He, Qun
Wang, Xiaoying
Xin, Zhongcheng
Li, Xuesong
Yu, Wei
Fang, Dong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To elucidate the characteristics and risk factors for positive biopsy outcomes in Chinese patients with prostate specific antigen (PSA) 4–10 ng/mL and develop a risk-stratification score model.
Methods.
The data of 345 patients who underwent transrectal ultrasound-guided prostate biopsy between 2011 and 2013 was retrospectively analyzed.
Digital rectal examination (DRE), prostate volume (PV), magnetic resonance imaging (MRI), and smoking status were also collected.
Positive biopsy outcomes were defined as prostate cancer (PCa) and high grade PCa (HGPCa, Gleason Score≥7).
Results.
The median PSA was 7.15 (IQR 5.91–8.45) ng/mL.
Overall 138 patients (40.0%) were shown to have PCa, including 100 patients (29.0%) with HGPCa.
Smaller PV, elder age, MRI results, and positive DRE were proved to be predictive factors for positive biopsy outcomes in both univariate and multivariate analysis.
We developed a “PAMD” score which combined the four factors to categorize patients into three risk groups, and the model performed good predictive sensitivity and specificity.
Conclusion.
The prevalence of prostate cancer in Chinese patients with PSA 4–10 ng/mL was 40%, including 29% patients with high grade disease.
DRE, age, MRI, and PV were predictive factors for positive biopsy outcomes, and the PAMD score model could be utilized for risk-stratification and decision-making.
American Psychological Association (APA)
Fang, Dong& Ren, Da& Zhao, Chenglin& Li, Xuesong& Yu, Wei& Wang, Rui…[et al.]. 2015. Prevalence and Risk Factors of Prostate Cancer in Chinese Men with PSA 4–10 ngmL Who Underwent TRUS-Guided Prostate Biopsy: The Utilization of PAMD Score. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056065
Modern Language Association (MLA)
Fang, Dong…[et al.]. Prevalence and Risk Factors of Prostate Cancer in Chinese Men with PSA 4–10 ngmL Who Underwent TRUS-Guided Prostate Biopsy: The Utilization of PAMD Score. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056065
American Medical Association (AMA)
Fang, Dong& Ren, Da& Zhao, Chenglin& Li, Xuesong& Yu, Wei& Wang, Rui…[et al.]. Prevalence and Risk Factors of Prostate Cancer in Chinese Men with PSA 4–10 ngmL Who Underwent TRUS-Guided Prostate Biopsy: The Utilization of PAMD Score. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056065