Hepatocellular Carcinoma Growth Is Inhibited by Euphorbia helioscopia L. Extract in Nude Mice Xenografts
Joint Authors
Zhang, Youcheng
Cheng, Junsheng
Han, Wei
Wang, Zheyuan
Shao, Yuan
Wang, Yingzhen
Zhang, Yawu
Li, Zhongxin
Xu, Xiaodong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Euphorbia helioscopia L.
is a traditional Chinese medicine; recently research found that its ethyl acetate extract (EAE) plays an important role on tumor cell proliferation, apoptosis, invasion, and metastasis in vitro.
But the effect of EAE for tumor cells in vivo has not been reported.
To explore the inhibitory effect of EAE and molecular mechanism on hepatocellular carcinoma (HCC) SMMC-7721 cells in vivo, we utilized the nude mouse xenograft model of HCC.
Treated with EAE (50, 100, and 200 μg/mL), the volume of xenograft was measured during the entire process of EAE treatment.
In EAE treatment group, the volume of xenograft was significantly reduced compared with the control group (P<0.05) and the protein expressions of CyclinD1, bcl-2, and MMP-9 were reduced, while those of bax, caspase-3, and nm23-H1 were increased.
A significant change trend with increasing EAE concentrations has presented, compared with controls.
Moreover, the ultrastructural morphology of xenografts showed significant changes, including nuclear pyknosis and chromatin condensation, We found that EAE could effectively inhibit tumor growth, induce apoptosis, and inhibit tumor invasion and metastasis in vivo; it is suggested that EAE is a potential candidate for as a new anticancer agent.
American Psychological Association (APA)
Cheng, Junsheng& Han, Wei& Wang, Zheyuan& Shao, Yuan& Wang, Yingzhen& Zhang, Yawu…[et al.]. 2015. Hepatocellular Carcinoma Growth Is Inhibited by Euphorbia helioscopia L. Extract in Nude Mice Xenografts. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056079
Modern Language Association (MLA)
Cheng, Junsheng…[et al.]. Hepatocellular Carcinoma Growth Is Inhibited by Euphorbia helioscopia L. Extract in Nude Mice Xenografts. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056079
American Medical Association (AMA)
Cheng, Junsheng& Han, Wei& Wang, Zheyuan& Shao, Yuan& Wang, Yingzhen& Zhang, Yawu…[et al.]. Hepatocellular Carcinoma Growth Is Inhibited by Euphorbia helioscopia L. Extract in Nude Mice Xenografts. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056079