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N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms
Joint Authors
Imam, Mustapha Umar
Md Zamri, Nur Diyana
Azmi, Nur Hanisah
Ideris, Aini
Ismail, Maznah
Yida, Zhang
Wong, Waiteng
Altine Adamu, Hadiza
Abdullah, Maizaton Atmadini
Ismail, Norsharina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
N-Acetylneuraminic acid (Neu5Ac) is a biomarker of cardiometabolic diseases.
In the present study, we tested the hypothesis that dietary Neu5Ac may improve cardiometabolic indices.
A high fat diet (HFD) + Neu5Ac (50 or 400 mg/kg BW/day) was fed to rats and compared with HFD + simvastatin (10 mg/kg BW/day) or HFD alone for 12 weeks.
Weights and serum biochemicals (lipid profile, oral glucose tolerance test, leptin, adiponectin, and insulin) were measured, and mRNA levels of insulin signaling genes were determined.
The results indicated that low and high doses of sialic acid (SA) improved metabolic indices, although only the oral glucose tolerance test, serum triglycerides, leptin, and adiponectin were significantly better than those in the HFD and HFD + simvastatin groups ( P < 0.05 ).
Furthermore, the results showed that only high-dose SA significantly affected the transcription of hepatic and adipose tissue insulin signaling genes.
The data suggested that SA prevented HFD-induced insulin resistance in rats after 12 weeks of administration through nontranscriptionally mediated biochemical changes that may have differentially sialylated glycoprotein structures at a low dose.
At higher doses, SA induced transcriptional regulation of insulin signaling genes.
These effects suggest that low and high doses of SA may produce similar metabolic outcomes in relation to insulin sensitivity through multiple mechanisms.
These findings are worth studying further.
American Psychological Association (APA)
Yida, Zhang& Imam, Mustapha Umar& Ismail, Maznah& Ismail, Norsharina& Azmi, Nur Hanisah& Wong, Waiteng…[et al.]. 2015. N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056082
Modern Language Association (MLA)
Yida, Zhang…[et al.]. N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056082
American Medical Association (AMA)
Yida, Zhang& Imam, Mustapha Umar& Ismail, Maznah& Ismail, Norsharina& Azmi, Nur Hanisah& Wong, Waiteng…[et al.]. N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056082