Influence of Immunogenicity on the Efficacy of Long-Term Treatment with TNF α Blockers in Rheumatoid Arthritis and Spondyloarthritis Patients
Joint Authors
Arstikyte, Inesa
Kapleryte, Giedre
Butrimiene, Irena
Venalis, Algirdas
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To analyze the clinical relevance of the levels of TNFα blockers and anti-drug antibodies (anti-drug Ab) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) treated with adalimumab (ADA), etanercept (ETA), or infliximab (INF) for a prolonged period of time.
Methods.
Clinical characteristics (disease activity, and adverse events), serum TNFα blockers, and anti-drug Ab levels were evaluated in 62 RA and 81 SpA patients treated with TNFα blockers for a median of 28 months.
Results.
Anti-ADA Ab were detected in 1 (4.0%) and anti-INF Ab in 14 out of 57 (24.6%) RA and SpA patients.
Patient with anti-ADA Ab and 57.1% patients with anti-INF Ab were considered nonresponders to treatment.
Anti-ETA Ab were not found in any of 61 ETA treated patients.
Anti-ADA and anti-INF Ab levels differ between responders and nonresponders ( P > 0.05 ) .
Three (5.3%) patients with high serum anti-INF Ab levels developed infusion related reactions.
Patients with anti-INF Ab more often required changing to another biologic drug (OR 11.43 (95% CI 1.08–120.93)) and treatment discontinuation (OR 9.28 (95% CI 1.64–52.52)).
Conclusion.
Patients not responding to treatment had higher serum anti-ADA and anti-INF Ab concentrations.
Anti-INF Ab formation is related to increased risk of infusion related reactions, changing to another biologic drug, and treatment discontinuation.
American Psychological Association (APA)
Arstikyte, Inesa& Kapleryte, Giedre& Butrimiene, Irena& Venalis, Algirdas. 2015. Influence of Immunogenicity on the Efficacy of Long-Term Treatment with TNF α Blockers in Rheumatoid Arthritis and Spondyloarthritis Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056092
Modern Language Association (MLA)
Arstikyte, Inesa…[et al.]. Influence of Immunogenicity on the Efficacy of Long-Term Treatment with TNF α Blockers in Rheumatoid Arthritis and Spondyloarthritis Patients. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056092
American Medical Association (AMA)
Arstikyte, Inesa& Kapleryte, Giedre& Butrimiene, Irena& Venalis, Algirdas. Influence of Immunogenicity on the Efficacy of Long-Term Treatment with TNF α Blockers in Rheumatoid Arthritis and Spondyloarthritis Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056092