Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia
Joint Authors
Han, Junyan
Ma, Deshun
Zhang, Miao
Yang, Xuelian
Tan, Dehong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The effect of betanin on a rat paraquat-induced acute lung injury (ALI) model was investigated.
Paraquat was injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) was orally administered 3 days before and 2 days after paraquat administration.
Rats were sacrificed 24 hours after the last betanin dosage, and lung tissue and bronchoalveolar lavage fluid (BALF) were collected.
In rats treated only with paraquat, extensive lung injury characteristic of ALI was observed, including histological changes, elevation of lung : body weight ratio, increased lung permeability, increased lung neutrophilia infiltration, increased malondialdehyde (MDA) and myeloperoxidase (MPO) activity, reduced superoxide dismutase (SOD) activity, reduced claudin-4 and zonula occluden-1 protein levels, increased BALF interleukin (IL-1) and tumor necrosis factor (TNF)-α levels, reduced BALF IL-10 levels, and increased lung nuclear factor kappa (NF-κB) activity.
In rats treated with betanin, paraquat-induced ALI was attenuated in a dose-dependent manner.
In conclusion, our results indicate that betanin attenuates paraquat-induced ALI possibly via antioxidant and anti-inflammatory mechanisms.
Thus, the potential for using betanin as an auxilliary therapy for ALI should be explored further.
American Psychological Association (APA)
Han, Junyan& Ma, Deshun& Zhang, Miao& Yang, Xuelian& Tan, Dehong. 2015. Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056107
Modern Language Association (MLA)
Han, Junyan…[et al.]. Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056107
American Medical Association (AMA)
Han, Junyan& Ma, Deshun& Zhang, Miao& Yang, Xuelian& Tan, Dehong. Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056107