Initial Experience of Sorafenib Neoadjuvant Therapy Combined with Retroperitoneoscopy in Treating T2 Large Renal Carcinoma

Joint Authors

Lin, Chun-hua
Yuan, He-jia
Wang, Ke
Wu, Ji-tao
Liu, Qing-zuo
Yu, Sheng-qiang
Men, Chang-ping
Gao, Zhen-li
Wang, Jiahui

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-09-03

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Objectives.

To investigate the safety and feasibility of sorafenib neoadjuvant therapy combined with retroperitoneoscopic radical nephrectomy (RRN) in treating T2 large renal cell carcinoma (RCC).

Methods.

Retrospectively analyzed 5 cases (2 males and 3 females, aged 52–73 years) of T2 stage large RCC who receive preoperative sorafenib targeted treatment (400 mg bid for 1–3 months) and RRN between March, 2013, and July, 2014.

Patient information, therapeutic regimen, drug adverse effect, tumor changes before and after surgery, and perioperative parameters were recorded.

Results.

During the sorafenib therapy adverse effects included 2 cases of hypertension (Grade I toxicity), 1 case of hand-foot syndrome (Grade I), and 1 case of diarrhea (Grade II), which were all tolerable for patients.

CT scan and histopathological tests confirmed significant reduction in the longest dimension (LD) and medium density (MD) of the tumor after therapy as well as tumor hemorrhage, necrosis, and cystic degeneration.

All 5 patients received RRN surgery successfully around 2 weeks after drug discontinuation with only 1 case of perioperative complication.

Conclusions.

Sorafenib neoadjuvant therapy could significantly reduce the size and aggressiveness of T2 large renal tumors, thus reducing the operative challenge and enabling patients who were previously disqualified for operation to receive surgical treatment.

American Psychological Association (APA)

Lin, Chun-hua& Yuan, He-jia& Wang, Ke& Wu, Ji-tao& Liu, Qing-zuo& Yu, Sheng-qiang…[et al.]. 2015. Initial Experience of Sorafenib Neoadjuvant Therapy Combined with Retroperitoneoscopy in Treating T2 Large Renal Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056113

Modern Language Association (MLA)

Lin, Chun-hua…[et al.]. Initial Experience of Sorafenib Neoadjuvant Therapy Combined with Retroperitoneoscopy in Treating T2 Large Renal Carcinoma. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056113

American Medical Association (AMA)

Lin, Chun-hua& Yuan, He-jia& Wang, Ke& Wu, Ji-tao& Liu, Qing-zuo& Yu, Sheng-qiang…[et al.]. Initial Experience of Sorafenib Neoadjuvant Therapy Combined with Retroperitoneoscopy in Treating T2 Large Renal Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056113

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1056113