Contrast-Enhanced Ultrasonography Features of Breast Malignancies with Different Sizes: Correlation with Prognostic Factors
Joint Authors
Zhao, Li-Xia
Liu, Hui
Wei, Qing
Xu, Guang
Wu, Jian
Wu, Rong
Pu, Huan
Xu, Hui-Xiong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study was to investigate the correlation between contrast-enhanced ultrasonography (CEUS) characteristics with prognostic factors in breast cancers with different sizes.
A retrospective analysis of CEUS characteristics of 104 pathologically proven malignant lesions from 104 women was conducted.
Lesions were divided into two groups according to their size measured by US (Group 1: maximum diameter ≤20 mm; Group 2: maximum diameter >20 mm).
Features including enhancement degree, order and pattern, enlargement of the enhancement area, and penetrating vessels on CEUS were evaluated.
Pathologic prognostic factors, including estrogen and progesterone receptor status, and the expression of c-erb-B2, p53, Ki-67, and VEGF were assessed.
Comparison of enhancement pattern parameters between Group 1 and Group 2 showed statistically significant differences ( P < 0.0 001 ).
A significant correlation was found between enlargement of the enhancement area and ER positivity in Group 1 ( P = 0.032 ).
In Group 2 the absence of penetrating vessels was significantly associated with VEGF negativity ( P = 0.022 ) and ER negativity ( P = 0.022 ).
Centripetal enhancement reflected VEGF negativity ( P = 0.033 ) in lesions with diameter >20 mm.
Thus, breast cancers with different sizes show different CEUS features; small breast cancers show homogeneous enhancement pattern while cancers with diameter >20 mm show homogeneous enhancement pattern.
Some CEUS characteristics of differently sized breast cancers could be correlated with prognostic factors, which may be useful in prognosis assessment.
American Psychological Association (APA)
Zhao, Li-Xia& Liu, Hui& Wei, Qing& Xu, Guang& Wu, Jian& Xu, Hui-Xiong…[et al.]. 2015. Contrast-Enhanced Ultrasonography Features of Breast Malignancies with Different Sizes: Correlation with Prognostic Factors. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056128
Modern Language Association (MLA)
Zhao, Li-Xia…[et al.]. Contrast-Enhanced Ultrasonography Features of Breast Malignancies with Different Sizes: Correlation with Prognostic Factors. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056128
American Medical Association (AMA)
Zhao, Li-Xia& Liu, Hui& Wei, Qing& Xu, Guang& Wu, Jian& Xu, Hui-Xiong…[et al.]. Contrast-Enhanced Ultrasonography Features of Breast Malignancies with Different Sizes: Correlation with Prognostic Factors. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056128