Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members
Joint Authors
Zhou, Tianyu
Yan, Xiping
Wang, Guosong
Liu, Hehe
Gan, Xiang
Zhang, Tao
Wang, Jiwen
Li, Liang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ in functions.
The purpose of this study is to investigate the evolutionary impacts on diversity functions of PPAR members and the regulatory differences on gene expression patterns.
63 homology sequences of PPAR genes from 31 species were collected and analyzed.
The results showed that three isolated types of PPAR gene family may emerge from twice times of gene duplication events.
The conserved domains of HOLI (ligand binding domain of hormone receptors) domain and ZnF_C4 (C4 zinc finger in nuclear in hormone receptors) are essential for keeping basic roles of PPAR gene family, and the variant domains of LCRs may be responsible for their divergence in functions.
The positive selection sites in HOLI domain are benefit for PPARs to evolve towards diversity functions.
The evolutionary variants in the promoter regions and 3′ UTR regions of PPARs result into differential transcription factors and miRNAs involved in regulating PPAR members, which may eventually affect their expressions and tissues distributions.
These results indicate that gene duplication event, selection pressure on HOLI domain, and the variants on promoter and 3′ UTR are essential for PPARs evolution and diversity functions acquired.
American Psychological Association (APA)
Zhou, Tianyu& Yan, Xiping& Wang, Guosong& Liu, Hehe& Gan, Xiang& Zhang, Tao…[et al.]. 2015. Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056129
Modern Language Association (MLA)
Zhou, Tianyu…[et al.]. Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056129
American Medical Association (AMA)
Zhou, Tianyu& Yan, Xiping& Wang, Guosong& Liu, Hehe& Gan, Xiang& Zhang, Tao…[et al.]. Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056129