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Reactive Oxygen Species, Apoptosis, and Mitochondrial Dysfunction in Hearing Loss
Joint Authors
Yamasoba, Tatsuya
Fujimoto, Chisato
Kamogashira, Teru
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Reactive oxygen species (ROS) production is involved in several apoptotic and necrotic cell death pathways in auditory tissues.
These pathways are the major causes of most types of sensorineural hearing loss, including age-related hearing loss, hereditary hearing loss, ototoxic drug-induced hearing loss, and noise-induced hearing loss.
ROS production can be triggered by dysfunctional mitochondrial oxidative phosphorylation and increases or decreases in ROS-related enzymes.
Although apoptotic cell death pathways are mostly activated by ROS production, there are other pathways involved in hearing loss that do not depend on ROS production.
Further studies of other pathways, such as endoplasmic reticulum stress and necrotic cell death, are required.
American Psychological Association (APA)
Kamogashira, Teru& Fujimoto, Chisato& Yamasoba, Tatsuya. 2015. Reactive Oxygen Species, Apoptosis, and Mitochondrial Dysfunction in Hearing Loss. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056139
Modern Language Association (MLA)
Kamogashira, Teru…[et al.]. Reactive Oxygen Species, Apoptosis, and Mitochondrial Dysfunction in Hearing Loss. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056139
American Medical Association (AMA)
Kamogashira, Teru& Fujimoto, Chisato& Yamasoba, Tatsuya. Reactive Oxygen Species, Apoptosis, and Mitochondrial Dysfunction in Hearing Loss. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056139