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Elevated Serum Levels of Soluble CD30 in Ankylosing Spondylitis Patients and Its Association with Disease Severity-Related Parameters
Joint Authors
Sun, Wei
Gao, Rongfen
Chen, Yu
Su, Yuying
Wang, Chenqiong
Dong, Lingli
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Soluble CD30 (sCD30), a transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily, has been shown to be associated with various pathological conditions.
This study was designed to measure the levels of serum sCD30 in patients with ankylosing spondylitis (AS) and to evaluate the relationships between serum sCD30 levels and other disease severity-related indexes, including bath ankylosing spondylitis disease activity index (BASDAI), ankylosing spondylitis disease activity score (ASDAS), and bath ankylosing spondylitis functional index (BASFI).
Our results demonstrated significantly elevated sCD30 levels in AS patients compared to healthy controls (HCs) with mean values of 32.0±12.2 and 24.9±8.0 ng/mL, respectively (P**=0.007), suggesting a potential role of sCD30 in the pathogenesis of AS.
However, no significant correlations of sCD30 with BASDAI, ASDAS, or BASFI were detected in our study (P>0.05).
Therefore, sCD30 cannot be used as a reliable marker for reflecting disease activity and functional ability of AS patients.
American Psychological Association (APA)
Gao, Rongfen& Sun, Wei& Chen, Yu& Su, Yuying& Wang, Chenqiong& Dong, Lingli. 2015. Elevated Serum Levels of Soluble CD30 in Ankylosing Spondylitis Patients and Its Association with Disease Severity-Related Parameters. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056140
Modern Language Association (MLA)
Gao, Rongfen…[et al.]. Elevated Serum Levels of Soluble CD30 in Ankylosing Spondylitis Patients and Its Association with Disease Severity-Related Parameters. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056140
American Medical Association (AMA)
Gao, Rongfen& Sun, Wei& Chen, Yu& Su, Yuying& Wang, Chenqiong& Dong, Lingli. Elevated Serum Levels of Soluble CD30 in Ankylosing Spondylitis Patients and Its Association with Disease Severity-Related Parameters. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056140