Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value

Joint Authors

Zhang, Wei
Wang, Lin
Zheng, Fang
Zou, Ruhai
Xie, Changqing
Guo, Qiannan
Hu, Qian
Chen, Jianing
Yang, Xing
Yao, Herui
Song, Erwei
Xiang, Yanqun

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-09-13

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Medicine

Abstract EN

Long noncoding RNAs (lncRNAs) have recently been found to play important roles in various cancer types.

The elucidation of genome-wide lncRNA expression patterns in metastatic nasopharyngeal carcinoma (NPC) could reveal novel mechanisms underlying NPC carcinogenesis and progression.

In this study, lncRNA expression profiling was performed on metastatic and primary NPC tumors, and the differentially expressed lncRNAs between these samples were identified.

A total of 33,045 lncRNA probes were generated for our microarray based on authoritative data sources, including RefSeq, UCSC Knowngenes, Ensembl, and related literature.

Using these probes, 8,088 lncRNAs were found to be significantly differentially expressed ( ≥ 2-fold).

To identify the prognostic value of these differentially expressed lncRNAs, four lncRNAs (LOC84740, ENST00000498296, AL359062, and ENST00000438550) were selected; their expression levels were measured in an independent panel of 106 primary NPC samples via QPCR.

Among these lncRNAs, ENST00000438550 expression was demonstrated to be significantly correlated with NPC disease progression.

A survival analysis showed that a high expression level of ENST00000438550 was an independent indicator of disease progression in NPC patients ( P = 0.01 ).

In summary, this study may provide novel diagnostic and prognostic biomarkers for NPC, as well as a novel understanding of the mechanism underlying NPC metastasis and potential targets for future treatment.

American Psychological Association (APA)

Zhang, Wei& Wang, Lin& Zheng, Fang& Zou, Ruhai& Xie, Changqing& Guo, Qiannan…[et al.]. 2015. Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056150

Modern Language Association (MLA)

Zhang, Wei…[et al.]. Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1056150

American Medical Association (AMA)

Zhang, Wei& Wang, Lin& Zheng, Fang& Zou, Ruhai& Xie, Changqing& Guo, Qiannan…[et al.]. Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056150

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1056150