Image-Based Structural Modeling of the Cardiac Purkinje Network
Joint Authors
Cherry, Elizabeth M.
Liu, Benjamin R.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction.
Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the genesis and maintenance of ventricular arrhythmias.
Despite its importance, few structural models of the Purkinje network have been developed, primarily because current physical limitations prevent examination of the intact Purkinje network.
In previous modeling efforts Purkinje-like structures have been developed through either automated or hand-drawn procedures, but these networks have been created according to general principles rather than based on real networks.
To allow for greater realism in Purkinje structural models, we present a method for creating three-dimensional Purkinje networks based directly on imaging data.
Our approach uses Purkinje network structures extracted from photographs of dissected ventricles and projects these flat networks onto realistic endocardial surfaces.
Using this method, we create models for the combined ventricle-Purkinje system that can fully activate the ventricles through a stimulus delivered to the Purkinje network and can produce simulated activation sequences that match experimental observations.
The combined models have the potential to help elucidate Purkinje network contributions during ventricular arrhythmias.
American Psychological Association (APA)
Liu, Benjamin R.& Cherry, Elizabeth M.. 2015. Image-Based Structural Modeling of the Cardiac Purkinje Network. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056157
Modern Language Association (MLA)
Liu, Benjamin R.& Cherry, Elizabeth M.. Image-Based Structural Modeling of the Cardiac Purkinje Network. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1056157
American Medical Association (AMA)
Liu, Benjamin R.& Cherry, Elizabeth M.. Image-Based Structural Modeling of the Cardiac Purkinje Network. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056157