Preclinical Murine Models for Lung Cancer: Clinical Trial Applications
Joint Authors
Morris, Don G.
Kellar, Amelia
Egan, Cay
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Murine models for the study of lung cancer have historically been the backbone of preliminary preclinical data to support early human clinical trials.
However, the availability of multiple experimental systems leads to debate concerning which model, if any, is best suited for a particular therapeutic strategy.
It is imperative that these models accurately predict clinical benefit of therapy.
This review provides an overview of the current murine models used to study lung cancer and the advantages and limitations of each model, as well as a retrospective evaluation of the uses of each model with respect to accuracy in predicting clinical benefit of therapy.
A better understanding of murine models and their uses, as well as their limitations may aid future research concerning the development and implementation of new targeted therapies and chemotherapeutic agents for lung cancer.
American Psychological Association (APA)
Kellar, Amelia& Egan, Cay& Morris, Don G.. 2015. Preclinical Murine Models for Lung Cancer: Clinical Trial Applications. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056159
Modern Language Association (MLA)
Kellar, Amelia…[et al.]. Preclinical Murine Models for Lung Cancer: Clinical Trial Applications. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056159
American Medical Association (AMA)
Kellar, Amelia& Egan, Cay& Morris, Don G.. Preclinical Murine Models for Lung Cancer: Clinical Trial Applications. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056159