Smoldering Multiple Myeloma
Joint Authors
Gao, Minjie
Yang, Guang
Kong, Yuanyuan
Wu, Xiaosong
Shi, Jumei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Smoldering multiple myeloma (SMM) is an asymptomatic precursor stage of multiple myeloma (MM) characterized by clonal bone marrow plasma cells (BMPC) ≥ 10% and/or M protein level ≥ 30 g/L in the absence of end organ damage.
It represents an intermediate stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic MM.
The risk of progression to symptomatic MM is not uniform, and several parameters have been reported to predict the risk of progression.
These include the level of M protein and the percentage of BMPC, the proportion of immunophenotypically aberrant plasma cells, and the presence of immunoparesis, free light-chain (FLC) ratio, peripheral blood plasma cells (PBPC), pattern of serum M protein evolution, abnormal magnetic resonance imaging (MRI), cytogenetic abnormalities, IgA isotype, and Bence Jones proteinuria.
So far treatment is still not recommended for SMM, because several trials suggested that patients with SMM do not benefit from early treatment.
However, the Mateos et al.
trial showed a survival benefit after early treatment with lenalidomide plus dexamethasone in patients with high-risk SMM.
This trial has prompted a reevaluation of early treatment in an asymptomatic patient population.
American Psychological Association (APA)
Gao, Minjie& Yang, Guang& Kong, Yuanyuan& Wu, Xiaosong& Shi, Jumei. 2015. Smoldering Multiple Myeloma. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056166
Modern Language Association (MLA)
Gao, Minjie…[et al.]. Smoldering Multiple Myeloma. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056166
American Medical Association (AMA)
Gao, Minjie& Yang, Guang& Kong, Yuanyuan& Wu, Xiaosong& Shi, Jumei. Smoldering Multiple Myeloma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056166