Smoldering Multiple Myeloma

Joint Authors

Gao, Minjie
Yang, Guang
Kong, Yuanyuan
Wu, Xiaosong
Shi, Jumei

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-04-27

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Smoldering multiple myeloma (SMM) is an asymptomatic precursor stage of multiple myeloma (MM) characterized by clonal bone marrow plasma cells (BMPC) ≥ 10% and/or M protein level ≥ 30 g/L in the absence of end organ damage.

It represents an intermediate stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic MM.

The risk of progression to symptomatic MM is not uniform, and several parameters have been reported to predict the risk of progression.

These include the level of M protein and the percentage of BMPC, the proportion of immunophenotypically aberrant plasma cells, and the presence of immunoparesis, free light-chain (FLC) ratio, peripheral blood plasma cells (PBPC), pattern of serum M protein evolution, abnormal magnetic resonance imaging (MRI), cytogenetic abnormalities, IgA isotype, and Bence Jones proteinuria.

So far treatment is still not recommended for SMM, because several trials suggested that patients with SMM do not benefit from early treatment.

However, the Mateos et al.

trial showed a survival benefit after early treatment with lenalidomide plus dexamethasone in patients with high-risk SMM.

This trial has prompted a reevaluation of early treatment in an asymptomatic patient population.

American Psychological Association (APA)

Gao, Minjie& Yang, Guang& Kong, Yuanyuan& Wu, Xiaosong& Shi, Jumei. 2015. Smoldering Multiple Myeloma. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056166

Modern Language Association (MLA)

Gao, Minjie…[et al.]. Smoldering Multiple Myeloma. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056166

American Medical Association (AMA)

Gao, Minjie& Yang, Guang& Kong, Yuanyuan& Wu, Xiaosong& Shi, Jumei. Smoldering Multiple Myeloma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056166

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1056166