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Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
falafel (flfl) encodes a Drosophila homolog of human SMEK whose in vivo functions remain elusive.
In this study, we performed gain-of-function and loss-of-function analysis in Drosophila and identified flfl as a negative regulator of JNK pathway-mediated cell death.
While ectopic expression of flfl suppresses TNF-triggered JNK-dependent cell death, loss of flfl promotes JNK activation and cell death in the developing eye and wing.
These data report for the first time an essential physiological function of flfl in maintaining tissue homeostasis and organ development.
As the JNK signaling pathway has been evolutionary conserved from fly to human, a similar role of PP4R3 in JNK-mediated physiological process is speculated.
American Psychological Association (APA)
Huang, Jiuhong& Xue, Lei. 2015. Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056168
Modern Language Association (MLA)
Huang, Jiuhong& Xue, Lei. Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056168
American Medical Association (AMA)
Huang, Jiuhong& Xue, Lei. Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056168