Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract
Joint Authors
Afroz, Rizwana
Tanvir, E. M.
Khalil, Ibrahim
Ahmmed, Istiyak
Ahmed, Romana
Paul, Sudip
Alam, Nadia
Gan, Siew Hua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We investigated the protective role of Withania somnifera leaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats.
Subcutaneous injection of ISO (85 mg/kg body weight (b.w.)) administered to rats for two consecutive days caused a significant increase in cardiac troponin I (cTnI) levels and serum lipid profiles, as well as the activities of some marker enzymes.
In addition to these diagnostic markers, there were increased levels of lipid peroxidation (LPO) and decreased activities of enzymatic antioxidants (superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRx), and glutathione-S-transferase (GST)) in the myocardium.
However, oral pretreatment (100 mg/kg b.w.) with WSLEt for 4 weeks elicited a significant cardioprotective activity by lowering the levels of cTnI, lipid profiles, and marker enzymes.
The levels of LPO products were also significantly decreased.
Elevated activities of antioxidant enzymes were also observed in rats pretreated with WSLEt.
As further confirmed histopathologically, our findings strongly suggest that the cardioprotective effect of WSLEt on myocardium experiencing ISO-induced oxidative damage may be due to an augmentation of the endogenous antioxidant system and an inhibition of LPO in the myocardial membrane.
We conclude that WSLEt confers some protection against oxidative damage in ISO-induced MI in rats.
American Psychological Association (APA)
Khalil, Ibrahim& Ahmmed, Istiyak& Ahmed, Romana& Tanvir, E. M.& Afroz, Rizwana& Paul, Sudip…[et al.]. 2015. Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056174
Modern Language Association (MLA)
Khalil, Ibrahim…[et al.]. Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056174
American Medical Association (AMA)
Khalil, Ibrahim& Ahmmed, Istiyak& Ahmed, Romana& Tanvir, E. M.& Afroz, Rizwana& Paul, Sudip…[et al.]. Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056174