Estradiol Valerate Pretreatment in Short Protocol GnRH-Agonist Cycles versus Combined Pretreatment with Oral Contraceptive Pills in Long Protocol GnRH-Agonist Cycles: A Randomised Controlled Trial
Joint Authors
Liss, Joanna
Lukaszuk, Krzysztof
Kunicki, Michal
Kuczynski, Waldemar
Pastuszek, Ewa
Jakiel, Grzegorz
Zielinski, Krzysztof
Zabielska, Judyta
Plociennik, Lukasz
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The strategy of in vitro fertilization (IVF) procedures relies on the increasing pregnancy rate and decreasing the risk of premature ovulation and ovarian hyperstimulation syndrome.
They are also designed to avoid weekend oocyte retrievals.
Combined oral contraceptive (OC) pills are among the medicines used to accomplish these objectives.
Alternatively, estradiol can be used instead of OC to obtain similar results.
The aim of our study was to compare the differences in pregnancy rates (PRs), implantation rates, and miscarriage rates between a short agonist protocol with estradiol priming and a long protocol with combined OC.
Of the 298 women who participated in this study, 134 achieved clinical pregnancies (45.0%).
A higher PR (58.4%, n = 80 , compared to 40.3%, n = 54 ) was achieved in the long protocol after OC pretreatment group.
The implantation rate was also higher for this group (37.8% versus 28.0%; P = 0.03 ).
The miscarriage rate was 15.0% ( n = 12 ) for the long protocol after OC pretreatment group and 20.4% ( n = 11 ) for the short agonist group ( P = 0.81 ) .
The short agonist protocol required a 5.7% lower human menopausal gonadotropin (hMG) dosage than the long protocol but surprisingly the number of oocytes retrieved was also smaller.
American Psychological Association (APA)
Lukaszuk, Krzysztof& Liss, Joanna& Kunicki, Michal& Kuczynski, Waldemar& Pastuszek, Ewa& Jakiel, Grzegorz…[et al.]. 2015. Estradiol Valerate Pretreatment in Short Protocol GnRH-Agonist Cycles versus Combined Pretreatment with Oral Contraceptive Pills in Long Protocol GnRH-Agonist Cycles: A Randomised Controlled Trial. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056192
Modern Language Association (MLA)
Lukaszuk, Krzysztof…[et al.]. Estradiol Valerate Pretreatment in Short Protocol GnRH-Agonist Cycles versus Combined Pretreatment with Oral Contraceptive Pills in Long Protocol GnRH-Agonist Cycles: A Randomised Controlled Trial. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056192
American Medical Association (AMA)
Lukaszuk, Krzysztof& Liss, Joanna& Kunicki, Michal& Kuczynski, Waldemar& Pastuszek, Ewa& Jakiel, Grzegorz…[et al.]. Estradiol Valerate Pretreatment in Short Protocol GnRH-Agonist Cycles versus Combined Pretreatment with Oral Contraceptive Pills in Long Protocol GnRH-Agonist Cycles: A Randomised Controlled Trial. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056192