A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines
Joint Authors
Rosas-Pérez, Jaiver E.
García-Castañeda, Javier E.
Rivera-Monroy, Zuly J.
Solarte, Víctor A.
Arango-Rodríguez, Martha L.
Vernot, Jean-Paul
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Several short linear peptides derived from cyclic bovine lactoferricin were synthesized and tested for their cytotoxic effect against the oral cavity squamous-cell carcinoma (OSCC) cell lines CAL27 and SCC15.
As a control, an immortalized and nontumorigenic cell line, Het-1A, was used.
Linear peptides based on the RRWQWR core sequence showed a moderate cytotoxic effect and specificity towards tumorigenic cells.
A tetrameric peptide, LfcinB(20–25)4, containing the RRWQWR motif, exhibited greater cytotoxic activity (>90%) in both OSCC cell lines compared to the linear lactoferricin peptide or the lactoferrin protein.
Additionally, this tetrameric peptide showed the highest specificity towards tumorigenic cells among the tested peptides.
Interestingly, this effect was very fast, with cell shrinkage, severe damage to cell membrane permeability, and lysis within one hour of treatment.
Our results are consistent with a necrotic effect rather than an apoptotic one and suggest that this tetrameric peptide could be considered as a new candidate for the therapeutic treatment of OSCC.
American Psychological Association (APA)
Solarte, Víctor A.& Rosas-Pérez, Jaiver E.& Rivera-Monroy, Zuly J.& Arango-Rodríguez, Martha L.& García-Castañeda, Javier E.& Vernot, Jean-Paul. 2015. A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056203
Modern Language Association (MLA)
Solarte, Víctor A.…[et al.]. A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1056203
American Medical Association (AMA)
Solarte, Víctor A.& Rosas-Pérez, Jaiver E.& Rivera-Monroy, Zuly J.& Arango-Rodríguez, Martha L.& García-Castañeda, Javier E.& Vernot, Jean-Paul. A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056203