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Behaviour of Endothelial Cells in a Tridimensional In Vitro Environment
Joint Authors
Chabaud, Stéphane
Pouliot, Roxane
Ayata, Raif Eren
Auger, Michèle
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Angiogenesis is a fundamental process in healing, tumor growth, and a variety of medical conditions.
For this reason, in vitro angiogenesis is an area of interest for researchers.
Additionally, in vitro angiogenesis is important for the survival of prevascularized tissue-engineering models.
The aim of this study was to observe the self-tubular organization behaviour of endothelial cells in the self-assembly method.
In this study, bilayered and dermal substitutes were prepared using the self-assembly method.
Histological, immunostaining, and biochemical tests were performed.
The behavioural dynamics of endothelial cells in this biological environment of supportive cells were observed, as were the steps of the in vitro angiogenic cascade with self-organizing capillary-like structures formation.
The epidermal component of the substitutes was seen to promote network expansion and density.
It also increased the quantity of angiogenic factors (VEGF and Ang-1) without increasing the proinflammatory factor (IL-8).
In addition, the increased MMP activity contributed to matrix degradation, which facilitated capillary formation.
American Psychological Association (APA)
Ayata, Raif Eren& Chabaud, Stéphane& Auger, Michèle& Pouliot, Roxane. 2015. Behaviour of Endothelial Cells in a Tridimensional In Vitro Environment. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056205
Modern Language Association (MLA)
Ayata, Raif Eren…[et al.]. Behaviour of Endothelial Cells in a Tridimensional In Vitro Environment. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056205
American Medical Association (AMA)
Ayata, Raif Eren& Chabaud, Stéphane& Auger, Michèle& Pouliot, Roxane. Behaviour of Endothelial Cells in a Tridimensional In Vitro Environment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056205