Origins of the Vertebrate ErythroMegakaryocytic System
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Vertebrate erythrocytes and thrombocytes arise from the common bipotent thrombocytic-erythroid progenitors (TEPs).
Even though nonmammalian erythrocytes and thrombocytes are phenotypically very similar to each other, mammalian species have developed some key evolutionary improvements in the process of erythroid and thrombocytic differentiation, such as erythroid enucleation, megakaryocyte endoreduplication, and platelet formation.
This brings up a few questions that we try to address in this review.
Specifically, we describe the ontology of erythro-thrombopoiesis during adult hematopoiesis with focus on the phylogenetic origin of mammalian erythrocytes and thrombocytes (also termed platelets).
Although the evolutionary relationship between mammalian and nonmammalian erythroid cells is clear, the appearance of mammalian megakaryocytes is less so.
Here, we discuss recent data indicating that nonmammalian thrombocytes and megakaryocytes are homologs.
Finally, we hypothesize that erythroid and thrombocytic differentiation evolved from a single ancestral lineage, which would explain the striking similarities between these cells.
American Psychological Association (APA)
Svoboda, Ondrej& Bartunek, Petr. 2015. Origins of the Vertebrate ErythroMegakaryocytic System. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056213
Modern Language Association (MLA)
Svoboda, Ondrej& Bartunek, Petr. Origins of the Vertebrate ErythroMegakaryocytic System. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056213
American Medical Association (AMA)
Svoboda, Ondrej& Bartunek, Petr. Origins of the Vertebrate ErythroMegakaryocytic System. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056213