Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs
Joint Authors
Bai, Yanyang
Xiang, Xiaoliang
Liang, Chunmei
Shi, Lei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Rho family GTPases, including RhoA, Rac1, and Cdc42 as the most studied members, are master regulators of actin cytoskeletal organization.
Rho GTPases control various aspects of the nervous system and are associated with a number of neuropsychiatric and neurodegenerative diseases.
The activity of Rho GTPases is controlled by two families of regulators, guanine nucleotide exchange factors (GEFs) as the activators and GTPase-activating proteins (GAPs) as the inhibitors.
Through coordinated regulation by GEFs and GAPs, Rho GTPases act as converging signaling molecules that convey different upstream signals in the nervous system.
So far, more than 70 members of either GEFs or GAPs of Rho GTPases have been identified in mammals, but only a small subset of them have well-known functions.
Thus, characterization of important GEFs and GAPs in the nervous system is crucial for the understanding of spatiotemporal dynamics of Rho GTPase activity in different neuronal functions.
In this review, we summarize the current understanding of GEFs and GAPs for Rac1, with emphasis on the molecular function and disease implication of these regulators in the nervous system.
American Psychological Association (APA)
Bai, Yanyang& Xiang, Xiaoliang& Liang, Chunmei& Shi, Lei. 2015. Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056214
Modern Language Association (MLA)
Bai, Yanyang…[et al.]. Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056214
American Medical Association (AMA)
Bai, Yanyang& Xiang, Xiaoliang& Liang, Chunmei& Shi, Lei. Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056214