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Overcoming Multidrug Resistance in Cancer Stem Cells
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The principle mechanism of protection of stem cells is through the expression of ATP-binding cassette (ABC) transporters.
These transporters serve as the guardians of the stem cell population in the body.
Unfortunately these very same ABC efflux pumps afford protection to cancer stem cells in tumors, shielding them from the adverse effects of chemotherapy.
A number of strategies to circumvent the function of these transporters in cancer stem cells are currently under investigation.
These strategies include the development of competitive and allosteric modulators, nanoparticle mediated delivery of inhibitors, targeted transcriptional regulation of ABC transporters, miRNA mediated inhibition, and targeting of signaling pathways that modulate ABC transporters.
The role of ABC transporters in cancer stem cells will be explored in this paper and strategies aimed at overcoming drug resistance caused by these particular transporters will also be discussed.
American Psychological Association (APA)
Moitra, Karobi. 2015. Overcoming Multidrug Resistance in Cancer Stem Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056223
Modern Language Association (MLA)
Moitra, Karobi. Overcoming Multidrug Resistance in Cancer Stem Cells. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056223
American Medical Association (AMA)
Moitra, Karobi. Overcoming Multidrug Resistance in Cancer Stem Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056223