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Zebrafish as a Model for the Study of Human Myeloid Malignancies
Joint Authors
Lin, Liang-In
Lu, Jeng-Wei
Hsieh, Meng-Shan
Liao, Heng-An
Yang, Yi-Ju
Ho, Yi-Jung
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myeloid malignancies are heterogeneous disorders characterized by uncontrolled proliferation or/and blockage of differentiation of myeloid progenitor cells.
Although a substantial number of gene alterations have been identified, the mechanism by which these abnormalities interact has yet to be elucidated.
Over the past decades, zebrafish have become an important model organism, especially in biomedical research.
Several zebrafish models have been developed to recapitulate the characteristics of specific myeloid malignancies that provide novel insight into the pathogenesis of these diseases and allow the evaluation of novel small molecule drugs.
This report will focus on illustrative examples of applications of zebrafish models, including transgenesis, zebrafish xenograft models, and cell transplantation approaches, to the study of human myeloid malignancies.
American Psychological Association (APA)
Lu, Jeng-Wei& Hsieh, Meng-Shan& Liao, Heng-An& Yang, Yi-Ju& Ho, Yi-Jung& Lin, Liang-In. 2015. Zebrafish as a Model for the Study of Human Myeloid Malignancies. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056247
Modern Language Association (MLA)
Lu, Jeng-Wei…[et al.]. Zebrafish as a Model for the Study of Human Myeloid Malignancies. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056247
American Medical Association (AMA)
Lu, Jeng-Wei& Hsieh, Meng-Shan& Liao, Heng-An& Yang, Yi-Ju& Ho, Yi-Jung& Lin, Liang-In. Zebrafish as a Model for the Study of Human Myeloid Malignancies. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056247