Potential Therapeutic Benefit of Combining Gefitinib and Tamoxifen for Treating Advanced Lung Adenocarcinoma
Joint Authors
Liu, Chien-Ming
Chiu, Kuo-Liang
Chen, Tzu-Sheng
Chang, Shang-Miao
Yang, Shu-Yun
Chen, Li-Hsiou
Ni, Yung-Lun
Sher, Yuh-Pyng
Yu, Sung-Liang
Ma, Wen-Lung
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Epidermal growth factor receptor (EGFR) mutations are known as oncogene driver mutations and with EGFR mutations exhibit good response to the EGFR tyrosine kinase inhibitor Gefitinib.
Some studies have shown that activation of estrogen and estrogen receptor α or β (ERα/β) promote adenocarcinoma.
We evaluated the relationship between the two receptors and the potential therapeutic benefit with Gefitinib and Tamoxifen.
Methods.
We assessed the association between EGFR mutations as well as ERα/β expression/location and overall survival in a cohort of 55 patients with LAC from a single hospital.
PC9 (EGFR exon 19 deletion mutant; Gefitinib-vulnerable cells) and A549 (EGFR wild type; Gefitinib-resistant cells) cancer cells were used to evaluate the in vitro therapeutic benefits of combining Gefitinib and Tamoxifen.
Results.
We found that the cytosolic but not the nuclear expression of ERβ was associated with better OS in LAC tumors but not associated with EGFR mutation.
The in vitro study showed that combined Gefitinib and Tamoxifen resulted in increased apoptosis and cytosolic expression of ERβ.
In addition, combining both medications resulted in reduced cell growth and increased the cytotoxic effect of Gefitinib.
Conclusion.
Tamoxifen enhanced advanced LAC cytotoxic effect induced by Gefitinib by arresting ERβ in cytosol.
American Psychological Association (APA)
Liu, Chien-Ming& Chiu, Kuo-Liang& Chen, Tzu-Sheng& Chang, Shang-Miao& Yang, Shu-Yun& Chen, Li-Hsiou…[et al.]. 2015. Potential Therapeutic Benefit of Combining Gefitinib and Tamoxifen for Treating Advanced Lung Adenocarcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056251
Modern Language Association (MLA)
Liu, Chien-Ming…[et al.]. Potential Therapeutic Benefit of Combining Gefitinib and Tamoxifen for Treating Advanced Lung Adenocarcinoma. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056251
American Medical Association (AMA)
Liu, Chien-Ming& Chiu, Kuo-Liang& Chen, Tzu-Sheng& Chang, Shang-Miao& Yang, Shu-Yun& Chen, Li-Hsiou…[et al.]. Potential Therapeutic Benefit of Combining Gefitinib and Tamoxifen for Treating Advanced Lung Adenocarcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056251