Molecular Pathogenesis of Anti-NMDAR Encephalitis
Joint Authors
Ding, Hao
Jian, Zhihong
Stary, Creed M.
Yi, Wei
Xiong, Xiaoxing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Anti-NMDAR encephalitis is a recently identified autoimmune disease, described by an immune-mediated loss of NMDA glutamate receptors, resulting in progressive mental deterioration.
To date, literature on anti-NMDAR encephalitis has been largely clinically oriented, including descriptions of the clinical presentation and course, diagnostic methods, and potential clinical treatments.
However, the underlying molecular mechanisms contributing to the complex immunological cellular transformation that is associated with the progression of anti-NMDAR encephalitis remain to be adequately explored.
This review will provide a summary of the current literature on anti-NMDAR encephalitis, including the immunologic molecular mechanisms contributing to disease progression.
In particular this review will focus on the effect of anti-NMDAR on GluN2-NMDAR expression and the molecular transformation of B and T leukocytes in the loss of self-tolerance.
Further research on the immunologic mechanisms contributing to anti-NMDAR encephalitis may provide an avenue for future novel diagnostic approaches, such as immunologic surveillance, as well as new therapeutic strategies for this recently identified autoimmune disease.
American Psychological Association (APA)
Ding, Hao& Jian, Zhihong& Stary, Creed M.& Yi, Wei& Xiong, Xiaoxing. 2015. Molecular Pathogenesis of Anti-NMDAR Encephalitis. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056258
Modern Language Association (MLA)
Ding, Hao…[et al.]. Molecular Pathogenesis of Anti-NMDAR Encephalitis. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056258
American Medical Association (AMA)
Ding, Hao& Jian, Zhihong& Stary, Creed M.& Yi, Wei& Xiong, Xiaoxing. Molecular Pathogenesis of Anti-NMDAR Encephalitis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056258