Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet
Joint Authors
Ferramosca, Alessandra
Conte, Annalea
Zara, Vincenzo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In recent years, several studies focused their attention on the role of dietary fats in the pathogenesis of hepatic steatosis.
It has been demonstrated that a high-fat diet is able to induce hyperglycemia, hyperinsulinemia, obesity, and nonalcoholic fatty liver disease.
On the other hand, krill oil, a novel dietary supplement of n-3 PUFAs, has the ability to improve lipid and glucose metabolism, exerting possible protective effects against hepatic steatosis.
In this study we have investigated the effects of krill oil on mitochondrial energetic metabolism in animals fed a high-fat diet.
To this end, male Sprague-Dawley rats were divided into three groups and fed for 4 weeks with a standard diet (control group), a diet with 35% fat (HF group), or a high-fat diet supplemented with 2.5% krill oil (HF+KO group).
The obtained results suggest that krill oil promotes the burning of fat excess introduced by the high-fat diet.
This effect is obtained by stimulating mitochondrial metabolic pathways such as fatty acid oxidation, Krebs cycle, and respiratory chain complexes activity.
Modulation of the expression of carrier proteins involved in mitochondrial uncoupling was also observed.
Overall, krill oil counteracts the negative effects of a high-fat diet on mitochondrial energetic metabolism.
American Psychological Association (APA)
Ferramosca, Alessandra& Conte, Annalea& Zara, Vincenzo. 2015. Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056266
Modern Language Association (MLA)
Ferramosca, Alessandra…[et al.]. Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056266
American Medical Association (AMA)
Ferramosca, Alessandra& Conte, Annalea& Zara, Vincenzo. Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056266