GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Joint Authors
Vasquez-Soltero, Jessica Michelle
Pickart, Loren
Margolina, Anna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age.
It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair.
GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity of both metalloproteinases and their inhibitors.
It stimulates collagen, dermatan sulfate, chondroitin sulfate, and the small proteoglycan, decorin.
It also restores replicative vitality to fibroblasts after radiation therapy.
The molecule attracts immune and endothelial cells to the site of an injury.
It accelerates wound-healing of the skin, hair follicles, gastrointestinal tract, boney tissue, and foot pads of dogs.
It also induces systemic wound healing in rats, mice, and pigs.
In cosmetic products, it has been found to tighten loose skin and improve elasticity, skin density, and firmness, reduce fine lines and wrinkles, reduce photodamage, and hyperpigmentation, and increase keratinocyte proliferation.
GHK has been proposed as a therapeutic agent for skin inflammation, chronic obstructive pulmonary disease, and metastatic colon cancer.
It is capable of up- and downregulating at least 4,000 human genes, essentially resetting DNA to a healthier state.
The present review revisits GHK’s role in skin regeneration in the light of recent discoveries.
American Psychological Association (APA)
Pickart, Loren& Vasquez-Soltero, Jessica Michelle& Margolina, Anna. 2015. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056273
Modern Language Association (MLA)
Pickart, Loren…[et al.]. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056273
American Medical Association (AMA)
Pickart, Loren& Vasquez-Soltero, Jessica Michelle& Margolina, Anna. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056273