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Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone
Joint Authors
Muñoz-Durango, N.
Vecchiola, A.
Gonzalez-Gomez, L. M.
Simon, F.
Riedel, C. A.
Fardella, C. E.
Kalergis, Alexis M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The mineralocorticoid receptor (MR) is a ligand dependent transcription factor.
MR has been traditionally associated with the control of water and electrolyte homeostasis in order to keep blood pressure through aldosterone activation.
However, there is growing evidence indicating that MR expression is not restricted to vascular and renal tissues, as it can be also expressed by cells of the immune system, where it responds to stimulation or antagonism, controlling immune cell function.
On the other hand, aldosterone also has been associated with proinflammatory immune effects, such as the release of proinflammatory cytokines, generating oxidative stress and inducing fibrosis.
The inflammatory participation of MR and aldosterone in the cardiovascular disease suggests an association with alterations in the immune system.
Hypertensive patients show higher levels of proinflammatory mediators that can be modulated by MR antagonism.
Although these proinflammatory properties have been observed in other autoimmune and chronic inflammatory diseases, the cellular and molecular mechanisms that mediate these effects remain unknown.
Here we review and discuss the scientific work aimed at determining the immunological role of MR and aldosterone in humans, as well as animal models.
American Psychological Association (APA)
Muñoz-Durango, N.& Vecchiola, A.& Gonzalez-Gomez, L. M.& Simon, F.& Riedel, C. A.& Fardella, C. E.…[et al.]. 2015. Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056301
Modern Language Association (MLA)
Muñoz-Durango, N.…[et al.]. Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1056301
American Medical Association (AMA)
Muñoz-Durango, N.& Vecchiola, A.& Gonzalez-Gomez, L. M.& Simon, F.& Riedel, C. A.& Fardella, C. E.…[et al.]. Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056301