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Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease
Joint Authors
Parenti, Rosalba
Gulino, Rosario
Gulisano, Massimo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A hopeful spinal cord repairing strategy involves the activation of neural precursor cells.
Unfortunately, their ability to generate neurons after injury appears limited.
Another process promoting functional recovery is synaptic plasticity.
We have previously studied some mechanisms of spinal plasticity involving BDNF, Shh, Notch-1, Numb, and Noggin, by using a mouse model of motoneuron depletion induced by cholera toxin-B saporin.
TDP-43 is a nuclear RNA/DNA binding protein involved in amyotrophic lateral sclerosis.
Interestingly, TDP-43 could be localized at the synapse and affect synaptic strength.
Here, we would like to deepen the investigation of this model of spinal plasticity.
After lesion, we observed a glial reaction and an activity-dependent modification of Shh, Noggin, and Numb proteins.
By using multivariate regression models, we found that Shh and Noggin could affect motor performance and that these proteins could be associated with both TDP-43 and Numb.
Our data suggest that TDP-43 is likely an important regulator of synaptic plasticity, probably in collaboration with other proteins involved in both neurogenesis and synaptic plasticity.
Moreover, given the rapidly increasing knowledge about spinal cord plasticity, we believe that further efforts to achieve spinal cord repair by stimulating the intrinsic potential of spinal cord will produce interesting results.
American Psychological Association (APA)
Gulino, Rosario& Parenti, Rosalba& Gulisano, Massimo. 2015. Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056306
Modern Language Association (MLA)
Gulino, Rosario…[et al.]. Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056306
American Medical Association (AMA)
Gulino, Rosario& Parenti, Rosalba& Gulisano, Massimo. Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056306