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On the Estimation of Heritability with Family-Based and Population-Based Samples
Joint Authors
Won, Sungho
Kim, Youngdoe
Lee, Young
Lee, Sungyoung
Kim, Nam Hee
Lim, Jeongmin
Kim, Young Jin
Oh, Ji Hee
Min, Haesook
Lee, Meehee
Seo, Hyeon-Jeong
Lee, So-Hyun
Sung, Joohon
Cho, Nam H.
Kim, Bong-Jo
Han, Bok-Ghee
Lee, Juyoung
Elston, Robert C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
For a family-based sample, the phenotypic variance-covariance matrix can be parameterized to include the variance of a polygenic effect that has then been estimated using a variance component analysis.
However, with the advent of large-scale genomic data, the genetic relationship matrix (GRM) can be estimated and can be utilized to parameterize the variance of a polygenic effect for population-based samples.
Therefore narrow sense heritability, which is both population and trait specific, can be estimated with both population- and family-based samples.
In this study we estimate heritability from both family-based and population-based samples, collected in Korea, and the heritability estimates from the pooled samples were, for height, 0.60; body mass index (BMI), 0.32; log-transformed triglycerides (log TG), 0.24; total cholesterol (TCHL), 0.30; high-density lipoprotein (HDL), 0.38; low-density lipoprotein (LDL), 0.29; systolic blood pressure (SBP), 0.23; and diastolic blood pressure (DBP), 0.24.
Furthermore, we found differences in how heritability is estimated—in particular the amount of variance attributable to common environment in twins can be substantial—which indicates heritability estimates should be interpreted with caution.
American Psychological Association (APA)
Kim, Youngdoe& Lee, Young& Lee, Sungyoung& Kim, Nam Hee& Lim, Jeongmin& Kim, Young Jin…[et al.]. 2015. On the Estimation of Heritability with Family-Based and Population-Based Samples. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056331
Modern Language Association (MLA)
Kim, Youngdoe…[et al.]. On the Estimation of Heritability with Family-Based and Population-Based Samples. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056331
American Medical Association (AMA)
Kim, Youngdoe& Lee, Young& Lee, Sungyoung& Kim, Nam Hee& Lim, Jeongmin& Kim, Young Jin…[et al.]. On the Estimation of Heritability with Family-Based and Population-Based Samples. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056331