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A Comparative Study on Multifactor Dimensionality Reduction Methods for Detecting Gene-Gene Interactions with the Survival Phenotype
Joint Authors
Kwon, Min-Seok
Lee, Seungyeoun
Kim, Yongkang
Park, Taesung
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Genome-wide association studies (GWAS) have extensively analyzed single SNP effects on a wide variety of common and complex diseases and found many genetic variants associated with diseases.
However, there is still a large portion of the genetic variants left unexplained.
This missing heritability problem might be due to the analytical strategy that limits analyses to only single SNPs.
One of possible approaches to the missing heritability problem is to consider identifying multi-SNP effects or gene-gene interactions.
The multifactor dimensionality reduction method has been widely used to detect gene-gene interactions based on the constructive induction by classifying high-dimensional genotype combinations into one-dimensional variable with two attributes of high risk and low risk for the case-control study.
Many modifications of MDR have been proposed and also extended to the survival phenotype.
In this study, we propose several extensions of MDR for the survival phenotype and compare the proposed extensions with earlier MDR through comprehensive simulation studies.
American Psychological Association (APA)
Lee, Seungyeoun& Kim, Yongkang& Kwon, Min-Seok& Park, Taesung. 2015. A Comparative Study on Multifactor Dimensionality Reduction Methods for Detecting Gene-Gene Interactions with the Survival Phenotype. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056332
Modern Language Association (MLA)
Lee, Seungyeoun…[et al.]. A Comparative Study on Multifactor Dimensionality Reduction Methods for Detecting Gene-Gene Interactions with the Survival Phenotype. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056332
American Medical Association (AMA)
Lee, Seungyeoun& Kim, Yongkang& Kwon, Min-Seok& Park, Taesung. A Comparative Study on Multifactor Dimensionality Reduction Methods for Detecting Gene-Gene Interactions with the Survival Phenotype. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056332