Activation of Sonic Hedgehog Leads to Survival Enhancement of Astrocytes via the GRP78-Dependent Pathway in Mice Infected with Angiostrongylus cantonensis
Joint Authors
Chen, Kuang-Yao
Cheng, Chien-Ju
Wang, Lian-Chen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Angiostrongylus cantonensis infection may cause elevation of ROS and antioxidants in the CSF of infected mice.
Astrocytes may protect the surrounding neurons from oxidative stress-induced cell death by secreting Sonic hedgehog (Shh) via the PI3-K/AKT/Bcl-2 pathway.
This study was conducted to determine the role of the Shh signaling pathway in A.
cantonensis-infected BABL/c mice by coculturing astrocytes with living fifth-stage larvae or soluble antigens.
The Shh pathway was activated with corresponding increases in the level of the Shh.
Glial fibrillary acidic protein (GFAP) and Shh were increased in astrocyte cocultured with living fifth-stage larvae or soluble antigens.
The survival of astrocytes pretreated with Shh was significantly elevated in cocultures with the antigens but reduced by its inhibitor cyclopamine.
The expression of GRP78 and Bcl-2 was significantly higher in astrocytes pretreated with recombinant Shh.
These findings suggest that the expression of Shh may inhibit cell death by activating Bcl-2 through a GRP78-dependent pathway.
American Psychological Association (APA)
Chen, Kuang-Yao& Cheng, Chien-Ju& Wang, Lian-Chen. 2015. Activation of Sonic Hedgehog Leads to Survival Enhancement of Astrocytes via the GRP78-Dependent Pathway in Mice Infected with Angiostrongylus cantonensis. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056345
Modern Language Association (MLA)
Chen, Kuang-Yao…[et al.]. Activation of Sonic Hedgehog Leads to Survival Enhancement of Astrocytes via the GRP78-Dependent Pathway in Mice Infected with Angiostrongylus cantonensis. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056345
American Medical Association (AMA)
Chen, Kuang-Yao& Cheng, Chien-Ju& Wang, Lian-Chen. Activation of Sonic Hedgehog Leads to Survival Enhancement of Astrocytes via the GRP78-Dependent Pathway in Mice Infected with Angiostrongylus cantonensis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056345