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The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients
Joint Authors
Rizk, Nasser M.
Egue, Huda
Souleman Wais, Idil
Mohamed Baluli, Hissa
Alali, Khalid
Farag, Fathi
El-Menyar, Ayman
al-Suwaidi, Jassim
Younes, Noura B. M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS).
Methods.
We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients.
Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS.
Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥50%)).
Results.
Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, P=0.026) than homozygous A allele carriers (GG versus AA).
Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, P=0.004) than carriers of the T alleles (AA versus GG).
The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30–0.92), P=0.038, among patients with significant stenosis.
Conclusions.
Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters.
In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.
American Psychological Association (APA)
Rizk, Nasser M.& El-Menyar, Ayman& Egue, Huda& Souleman Wais, Idil& Mohamed Baluli, Hissa& Alali, Khalid…[et al.]. 2015. The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056358
Modern Language Association (MLA)
Rizk, Nasser M.…[et al.]. The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056358
American Medical Association (AMA)
Rizk, Nasser M.& El-Menyar, Ayman& Egue, Huda& Souleman Wais, Idil& Mohamed Baluli, Hissa& Alali, Khalid…[et al.]. The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056358