Improvement of Endurance of DMD Animal Model Using Natural Polyphenols
Joint Authors
Meregalli, Mirella
Torrente, Yvan
Colleoni, Federica
Fortunato, Francesco
Razini, Paola
Erratico, Silvia
Tavelli, Alessandro
Fabrizi, Francesco
Belicchi, Marzia
Comi, Giacomo P.
Sitzia, Clementina
Farini, Andrea
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is characterized by muscular wasting caused by dystrophin deficiency that ultimately ends in force reduction and premature death.
In addition to primary genetic defect, several mechanisms contribute to DMD pathogenesis.
Recently, antioxidant supplementation was shown to be effective in the treatment of multiple diseases including muscular dystrophy.
Different mechanisms were hypothesized such as reduced hydroxyl radicals, nuclear factor-κB deactivation, and NO protection from inactivation.
Following these promising evidences, we investigated the effect of the administration of a mix of dietary natural polyphenols (ProAbe) on dystrophic mdx mice in terms of muscular architecture and functionality.
We observed a reduction of muscle fibrosis deposition and myofiber necrosis together with an amelioration of vascularization.
More importantly, the recovery of the morphological features of dystrophic muscle leads to an improvement of the endurance of treated dystrophic mice.
Our data confirmed that ProAbe-based diet may represent a strategy to coadjuvate the treatment of DMD.
American Psychological Association (APA)
Sitzia, Clementina& Farini, Andrea& Colleoni, Federica& Fortunato, Francesco& Razini, Paola& Erratico, Silvia…[et al.]. 2015. Improvement of Endurance of DMD Animal Model Using Natural Polyphenols. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056365
Modern Language Association (MLA)
Sitzia, Clementina…[et al.]. Improvement of Endurance of DMD Animal Model Using Natural Polyphenols. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056365
American Medical Association (AMA)
Sitzia, Clementina& Farini, Andrea& Colleoni, Federica& Fortunato, Francesco& Razini, Paola& Erratico, Silvia…[et al.]. Improvement of Endurance of DMD Animal Model Using Natural Polyphenols. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056365