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Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis
Joint Authors
Mesa, Francisco
Aneiros-Fernández, Jose
Padial-Molina, Miguel
Peregrina, Magdalena
Crespo-Lora, Vicente
Roman, Maria
Delgado, Mario
Aguilar, David
Gonzalez-Rey, Elena
Galindo-Moreno, Pablo
O'Valle, Francisco
Hernández-Cortés, Pedro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Collagen-induced arthritis (CIA), a murine experimental disease model induced by immunization with type II collagen (CII), is used to evaluate novel therapeutic strategies for rheumatoid arthritis.
Adult stem cell marker Musashi-1 (Msi1) plays an important role in regulating the maintenance and differentiation of stem/precursor cells.
The objectives of this investigation were to perform a morphological study of the experimental CIA model, evaluate the effect of TNFα-blocker (etanercept) treatment, and determine the immunohistochemical expression of Msi1 protein.
Methods.
CIA was induced in 50 male DBA1/J mice for analyses of tissue and serum cytokine; clinical and morphological lesions in limbs; and immunohistochemical expression of Msi1.
Results.
Clinically, TNFα-blocker treatment attenuated CIA on day 32 after immunization ( P < 0.001 ).
Msi1 protein expression was significantly higher in joints damaged by CIA than in those with no lesions ( P < 0.0001 ) and was related to the severity of the lesions (Spearman’s rho = 0.775, P = 0.0001 ).
Conclusions.
Treatment with etanercept attenuates osteoarticular lesions in the murine CIA model.
Osteoarticular expression of Msi1 protein is increased in joints with CIA-induced lesion and absent in nonlesioned joints, suggesting that this protein is expressed when the lesion is produced in order to favor tissue repair.
American Psychological Association (APA)
O'Valle, Francisco& Peregrina, Magdalena& Crespo-Lora, Vicente& Galindo-Moreno, Pablo& Roman, Maria& Padial-Molina, Miguel…[et al.]. 2015. Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056369
Modern Language Association (MLA)
O'Valle, Francisco…[et al.]. Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056369
American Medical Association (AMA)
O'Valle, Francisco& Peregrina, Magdalena& Crespo-Lora, Vicente& Galindo-Moreno, Pablo& Roman, Maria& Padial-Molina, Miguel…[et al.]. Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056369