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Construction of a gE-Deleted Pseudorabies Virus and Its Efficacy to the New-Emerging Variant PRV Challenge in the Form of Killed Vaccine
Joint Authors
Wang, Tongyan
Xiao, Yan
Yang, Qingyuan
Wang, Yuzhou
Sun, Zhe
Zhang, Chaoling
Yan, Shijun
Wang, Juan
Guo, Linghua
Yan, He
Gao, Zhiyu
Wang, Lilin
Li, Xiangdong
Tan, Feifei
Tian, Kegong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The new-emerging PRV variants plague the vaccinated pigs and caused huge economic loss to local pig industry in China since 2011.
The current commercial PRV vaccines cannot provide complete protection as the new-emerging PRV variants are antigenically different from the classical viruses.
It is urgent to develop more safe and effective PRV vaccines based on the current circulating field isolates.
In this study, a gE gene-deleted PRV based on the PRV HN1201, a representative PRV variant, was generated and the efficacy was tested on 3-week-old pigs in the form of killed vaccine.
After fatal PRV HN1201 challenge, all vaccinated pigs survived without showing any clinical symptoms, but all unvaccinated pigs exhibited pseudorabies-specific respiratory and neurological signs with 100% mortality rate within 6 days after infection.
The vaccinated pigs developed high level of gB and neutralizing antibodies after vaccination which may correlate to the protection provided by vaccine.
Therefore, this gE gene-deleted PRV could be a promising vaccine candidate for the control of currently epidemic pseudorabies in China.
American Psychological Association (APA)
Wang, Tongyan& Xiao, Yan& Yang, Qingyuan& Wang, Yuzhou& Sun, Zhe& Zhang, Chaoling…[et al.]. 2015. Construction of a gE-Deleted Pseudorabies Virus and Its Efficacy to the New-Emerging Variant PRV Challenge in the Form of Killed Vaccine. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056380
Modern Language Association (MLA)
Wang, Tongyan…[et al.]. Construction of a gE-Deleted Pseudorabies Virus and Its Efficacy to the New-Emerging Variant PRV Challenge in the Form of Killed Vaccine. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056380
American Medical Association (AMA)
Wang, Tongyan& Xiao, Yan& Yang, Qingyuan& Wang, Yuzhou& Sun, Zhe& Zhang, Chaoling…[et al.]. Construction of a gE-Deleted Pseudorabies Virus and Its Efficacy to the New-Emerging Variant PRV Challenge in the Form of Killed Vaccine. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056380