Factors Influencing the Eicosanoids Synthesis In Vivo
Joint Authors
Kruszewski, Wiesław Janusz
Sobczak, Ewa
Szefel, Jarosław
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
External factors activate a sequence of reactions involving the reception, transduction, and transmission of signals to effector cells.
There are two main phases of the body’s reaction to harmful factors: the first aims to neutralize the harmful factor, while in the second the inflammatory process is reduced in size and resolved.
Secondary messengers such as eicosanoids are active in both phases.
The discovery of lipoxins and epi-lipoxins demonstrated that not all arachidonic acid (AA) derivatives have proinflammatory activity.
It was also revealed that metabolites of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) such as resolvins, protectins, and maresins also take part in the resolution of inflammation.
Knowledge of the above properties has stimulated several clinical trials on the influence of EPA and DHA supplementation on various diseases.
However, the equivocal results of those trials prevent the formulation of guidelines on EPA and DHA supplementation.
Prescription drugs are among the substances with the strongest influence on the profile and quantity of the synthesized eicosanoids.
The lack of knowledge about their influence on the conversion of EPA and DHA into eicosanoids may lead to erroneous conclusions from clinical trials.
American Psychological Association (APA)
Szefel, Jarosław& Kruszewski, Wiesław Janusz& Sobczak, Ewa. 2015. Factors Influencing the Eicosanoids Synthesis In Vivo. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056402
Modern Language Association (MLA)
Szefel, Jarosław…[et al.]. Factors Influencing the Eicosanoids Synthesis In Vivo. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056402
American Medical Association (AMA)
Szefel, Jarosław& Kruszewski, Wiesław Janusz& Sobczak, Ewa. Factors Influencing the Eicosanoids Synthesis In Vivo. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056402