Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines
Joint Authors
Papachristou, Dionysios
Labropoulou, Vassiliki T.
Karamanos, Nikos K.
Theocharis, Achilleas D.
Korpetinou, Angeliki
Lampropoulou, Angeliki
Bouris, Panagiotis
Noulas, Argyrios
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In the present pilot study, we examined the presence of serglycin in lung, breast, prostate, and colon cancer and evaluated its expression in cell lines and tissues.
We found that serglycin was expressed and constitutively secreted in culture medium in high levels in more aggressive cancer cells.
It is worth noticing that aggressive cancer cells that harbor KRAS or EGFR mutations secreted serglycin constitutively in elevated levels.
Furthermore, we detected the transcription of an alternative splice variant of serglycin lacking exon 2 in specific cell lines.
In a limited number of tissue samples analyzed, serglycin was detected in normal epithelium but was also expressed in higher levels in advanced grade tumors as shown by immunohistochemistry.
Serglycin staining was diffuse, granular, and mainly cytoplasmic.
In some cancer cells serglycin also exhibited membrane and/or nuclear immunolocalization.
Interestingly, the stromal cells of the reactive tumor stroma were positive for serglycin, suggesting an enhanced biosynthesis for this proteoglycan in activated tumor microenvironment.
Our study investigated for first time the distribution of serglycin in normal epithelial and cancerous lesions in most common cancer types.
The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression.
American Psychological Association (APA)
Korpetinou, Angeliki& Papachristou, Dionysios& Lampropoulou, Angeliki& Bouris, Panagiotis& Labropoulou, Vassiliki T.& Noulas, Argyrios…[et al.]. 2015. Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056403
Modern Language Association (MLA)
Korpetinou, Angeliki…[et al.]. Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056403
American Medical Association (AMA)
Korpetinou, Angeliki& Papachristou, Dionysios& Lampropoulou, Angeliki& Bouris, Panagiotis& Labropoulou, Vassiliki T.& Noulas, Argyrios…[et al.]. Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056403