Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters
Joint Authors
Perlini, Stefano
Fiaccadori, Enrico
Cabassi, Aderville
Binno, Simone Maurizio
Tedeschi, Stefano
Graiani, Gallia
Galizia, Cinzia
Bianconcini, Michele
Coghi, Pietro
Fellini, Federica
Ruffini, Livia
Govoni, Paolo
Regolisti, Giuseppe
Piepoli, Massimo F.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rationale.
Heart failure (HF) is accompanied by the development of an imbalance between oxygen- and nitric oxide-derived free radical production leading to protein nitration.
Both chlorinating and peroxidase cycle of Myeloperoxidase (MPO) contribute to oxidative and nitrosative stress and are involved in tyrosine nitration of protein.
Ceruloplasmin (Cp) has antioxidant function through its ferroxidase I (FeOxI) activity and has recently been proposed as a physiological defense mechanism against MPO inappropriate actions.
Objective.
We investigated the relationship between plasma MPO-related chlorinating activity, Cp and FeOxI, and nitrosative stress, inflammatory, neurohormonal, and nutritional biomarkers in HF patients.
Methods and Results.
In chronic HF patients (n=81, 76 ± 9 years, NYHA Class II (26); Class III (29); Class IV (26)) and age-matched controls (n=17, 75 ± 11 years, CTR), plasma MPO chlorinating activity, Cp, FeOxI, nitrated protein, free Malondialdehyde, BNP, norepinephrine, hsCRP, albumin, and prealbumin were measured.
Plasma MPO chlorinating activity, Cp, BNP, norepinephrine, and hsCRP were increased in HF versus CTR.
FeOxI, albumin, and prealbumin were decreased in HF.
MPO-related chlorinating activity was positively related to Cp (r= 0.363, P<0.001), nitrated protein, hsCRP, and BNP and inversely to albumin.
Conclusions.
Plasma MPO chlorinated activity is increased in elderly chronic HF patients and positively associated with Cp, inflammatory, neurohormonal, and nitrosative parameters suggesting a role in HF progression.
American Psychological Association (APA)
Cabassi, Aderville& Binno, Simone Maurizio& Tedeschi, Stefano& Graiani, Gallia& Galizia, Cinzia& Bianconcini, Michele…[et al.]. 2015. Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056405
Modern Language Association (MLA)
Cabassi, Aderville…[et al.]. Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056405
American Medical Association (AMA)
Cabassi, Aderville& Binno, Simone Maurizio& Tedeschi, Stefano& Graiani, Gallia& Galizia, Cinzia& Bianconcini, Michele…[et al.]. Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056405