MyD88 Polymorphisms and Association with Susceptibility to Salmonella Pullorum
Joint Authors
Feng, Ze-Qing
Liu, Xian-Qing
Wang, Fei
Jin, Jie
Zhou, Yu-Guang
Ran, Jin-Shan
Wang, Yan
Liu, Yi-Ping
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Myeloid differentiation primary response gene 88 (MYD88), a universal adapter protein, plays an important role in activating the nuclear factor-κB (NF-κB) and regulating the expression of proinflammatory genes like tumor necrosis factor (TNF) and interleukin-1 (IL-1), which were highly involved in Salmonella Pullorum infection.
To detect the relationship between polymorphisms of the MyD88 gene and Salmonella Pullorum disease, we screened the coding region (CDS) of the MYD88 gene by DNA pool construction and sequencing based on case-control study.
Eight single nucleotide polymorphisms (SNPs) in the sequenced fragment (5 exons), 7 known loci and one novel mutation named G4810372T (SNP8), were found in the fifth exon.
In addition, we found 7 nonsynonymous substitutions.
The allele frequency of only one SNP, g.4810191C > T (SNP1), was significantly different ( P < 0.05 ) between case and control groups.
The genotype frequencies of SNP1 (g.4810191C > T) and SNP3 (g.4810257G > T) were of significant difference between the case and the control groups ( P < 0.05 ).
Collectively, SNPs of the MyD88 gene were significantly associated with susceptibility to Salmonella Pullorum infection, which can be used as a disease-resistant marker in chicken.
These results provided a theoretical basis for future research on chicken breeding by marker-assisted selection.
American Psychological Association (APA)
Liu, Xian-Qing& Wang, Fei& Jin, Jie& Zhou, Yu-Guang& Ran, Jin-Shan& Feng, Ze-Qing…[et al.]. 2015. MyD88 Polymorphisms and Association with Susceptibility to Salmonella Pullorum. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056407
Modern Language Association (MLA)
Liu, Xian-Qing…[et al.]. MyD88 Polymorphisms and Association with Susceptibility to Salmonella Pullorum. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056407
American Medical Association (AMA)
Liu, Xian-Qing& Wang, Fei& Jin, Jie& Zhou, Yu-Guang& Ran, Jin-Shan& Feng, Ze-Qing…[et al.]. MyD88 Polymorphisms and Association with Susceptibility to Salmonella Pullorum. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056407